ABSTRACT
Approximately 10% of transfusion associated hepatitis and 20% of community acquired hepatitis cases do not have a defined etiology, suggesting the existence of an additional causative agent. The recent agents which have been detected in blood were Hepatitis G virus (HGV) and TT virus (TTV), members of the family Circoviridae. These viruses were initially thought to be associated with post-transfusion hepatitis but later studies negated this causal effect. Recently, a novel DNA virus at the moment designated as SEN virus (SEN-V) was discovered and is thought to be associated with post-transfusion hepatitis. This virus is related to the above two agents and belongs to the same family. Whether, like HGV and TTV causal relationship with hepatitis is finally confirmed only time will tell, but, at the moment the association appears to present. The present review summarizes the present available data on this new agent of hepatitis.
Subject(s)
Hepatitis Viruses/classification , HumansABSTRACT
A great progress in the knowledge about hepatitis virus has occurred in the last decades and several virus have been identified. Virus B, C and D are transmitted parenterally, while virus A and E use the enteral route. Highly effective vaccines for A and B hepatitis are presently available. Virus C is an important cause of chronic liver disease at the present moment. Since the identification of virus C and E, the number of acute hepatitis denominated as non A non B has decreased considerable. Although there are still patients with viral hepatitis of unknown origin and there is considerable effort to identify the agents causing them. Virus G and TT are frequently present in the sera of patients with chronic liver diseases but their real pathogenic role is not completely elucidated
Subject(s)
Humans , Hepatitis, Viral, Human/etiology , Hepatitis Viruses/classification , Hepatitis B virus/isolation & purification , Hepatitis E virus/isolation & purification , Flaviviridae/isolation & purification , Hepatovirus/isolation & purification , Hepacivirus/isolation & purification , Hepatitis, Viral, Human/classification , Hepatitis, Viral, Human/diagnosisABSTRACT
Con el objeto de conocer la frecuencia de infección con el virus de la hepatitis tipo delta en nuestra población derechohabiente, se determinó la presencia de anticuerpos a este virus en 1012 personas con cuadros clínicos de hepatitis viral aguda o crónica, en las que se había encontrado la presencia de infección con el virus de la hepatitis viral del tipo B, en el Laboratorio Clínico del Hospital de Infectología del Centro Médico Nacional La Raza. Los resultados obtenidos mostraron una baja prevalencia de infección con este virus (1.58 por ciento), 16 de los 1012 pacientes estudiados, lo que coloca a nuestro país dentro de los considerados como de bajo nivel de endemicidad. La forma clínica más observada fue la de superinfección que dio lugar a cuadros clínicos que progresaron a hepatitis crónica (75.0 por ciento), el antecedente epidemiológico más frecuente fue el de hemotransfusión, en ningún caso se observó evolución a hepatitis fulminante, su presentación clínica indistinguible de otras formas agudas o crónicas de hepatitis dificultan su diagnóstico clínico